The CCNP ENCOR 350-401 exam covers a broad range of networking topics, including Layer 2 and Layer 3 technologies, wireless networking, and IP services. Key areas include troubleshooting trunking protocols and EtherChannels, configuring and verifying common STP, and understanding the routing concepts of EIGRP, OSPF, and BGP, as well as wireless networking principles. Additionally, the exam encompasses configuring and verifying NTP/PTP, NAT/PAT, HSRP/VRRP, and troubleshooting multicast protocols.